NSAID hypersensitivity (respiratory, cutaneous, and generalized anaphylactic symptoms)

Med Clin North Am. 2010 Jul;94(4):853-64, xiii. doi: 10.1016/j.mcna.2010.03.005. Epub 2010 May 13.


Adverse reactions to drugs have been classified as predictable (related to the pharmacologic actions of the drug) and unpredictable (related to the individual's immunologic response or genetic susceptibility). The term "drug hypersensitivity" refers to the symptoms or signs initiated by an exposure to a drug at a dose normally tolerated by nonhypersensitive persons. In this article, the current knowledge on hypersensitivity reactions to nonsteroidal antiinflammatory drugs is discussed.

Publication types

  • Review

MeSH terms

  • Anaphylaxis / chemically induced*
  • Angioedema / chemically induced
  • Anti-Inflammatory Agents, Non-Steroidal / adverse effects*
  • Cyclooxygenase 2 Inhibitors / adverse effects
  • Drug Hypersensitivity / diagnosis*
  • Drug Hypersensitivity / etiology
  • Humans
  • Respiratory Tract Diseases / chemically induced*
  • Risk Factors
  • Skin Diseases / chemically induced*
  • Urticaria / chemically induced


  • Anti-Inflammatory Agents, Non-Steroidal
  • Cyclooxygenase 2 Inhibitors