Primary unilateral multifocal pleomorphic adenoma of the parotid gland: molecular assessment and literature review

Head Neck Pathol. 2008 Dec;2(4):339-42. doi: 10.1007/s12105-008-0081-2. Epub 2008 Aug 28.


Multiple separate tumors developing in a single salivary gland is rare in previously untreated patients. Tumors that can be multicentric include Warthin tumor, oncocytoma, basal cell adenoma and acinic cell carcinoma. The incidence of multiple primary unilateral pleomorphic adenomas is extremely rare in patients with no prior history of trauma or surgery. We report two cases of primary multicentric pleomorphic adenoma and review the literature. We also subjected one of our cases to a molecular clonality test. The molecular results suggested that the separate nodules were clonally related, arguing against an independent origin.

Keywords: Multifocal; Parotid gland; Pleomorphic adenoma.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adenoma, Pleomorphic / genetics
  • Adenoma, Pleomorphic / pathology*
  • Adenoma, Pleomorphic / surgery
  • Aged
  • Clone Cells
  • DNA, Neoplasm / analysis
  • Female
  • Humans
  • Loss of Heterozygosity*
  • Neoplasms, Multiple Primary / genetics
  • Neoplasms, Multiple Primary / pathology*
  • Neoplasms, Multiple Primary / surgery
  • Parotid Neoplasms / genetics
  • Parotid Neoplasms / pathology*
  • Parotid Neoplasms / surgery


  • DNA, Neoplasm