Pharmacokinetic parameters in CNS Gd-DTPA enhanced MR imaging

J Comput Assist Tomogr. Jul-Aug 1991;15(4):621-8. doi: 10.1097/00004728-199107000-00018.

Abstract

Dynamic MR imaging can be used to study tissue perfusion and vascular permeability. In the present article a procedure for dynamic MR is presented, which (a) accurately resolves the fast kinetics of tissue response during and after intravenous infusion of the paramagnetic contrast medium Gd-DTPA and (b) yields a linear relationship between the measured MR signal and the Gd-DTPA concentration in the tissue. According to these features, the measured signal-time curves can be analyzed within the framework of pharmacokinetic modeling. Tissue response has been parameterized using a linear two-compartment open model, with only negligible effects of the peripheral compartment on the central compartment. The three model parameters were fitted to the signal-time data pixel by pixel, based on a set of 64 rapid SE images (SE 100/10 ms, image scan time 13 s, interscan intervals 11 s). This makes it possible to construct parameter images, whereby structures become visible that cannot be distinguished in conventional Gd-DTPA enhanced MR. As a clinical example, the approach is discussed in a case of glioblastoma.

Publication types

  • Case Reports

MeSH terms

  • Brain Neoplasms / diagnosis
  • Brain Neoplasms / metabolism
  • Contrast Media / pharmacokinetics*
  • Female
  • Gadolinium / pharmacokinetics*
  • Gadolinium DTPA
  • Glioma / diagnosis
  • Glioma / metabolism
  • Humans
  • Magnetic Resonance Imaging*
  • Middle Aged
  • Organometallic Compounds / pharmacokinetics*
  • Pentetic Acid / pharmacokinetics*

Substances

  • Contrast Media
  • Organometallic Compounds
  • Pentetic Acid
  • Gadolinium
  • Gadolinium DTPA