Treatment of acyclovir-resistant herpes simplex virus with continuous infusion of high-dose acyclovir in hematopoietic cell transplant patients

Janet H Kim; Joanna M Schaenman; Dora Y Ho; Janice M Y Brown

doi:10.1016/j.bbmt.2010.06.020

Treatment of acyclovir-resistant herpes simplex virus with continuous infusion of high-dose acyclovir in hematopoietic cell transplant patients

Biol Blood Marrow Transplant. 2011 Feb;17(2):259-64. doi: 10.1016/j.bbmt.2010.06.020. Epub 2010 Jul 6.

Authors

Janet H Kim¹, Joanna M Schaenman, Dora Y Ho, Janice M Y Brown

Affiliation

¹ Department of Medicine, Stanford University School of Medicine, Stanford, California, USA.

PMID: 20615475
DOI: 10.1016/j.bbmt.2010.06.020

Abstract

Infection because of herpes simplex virus (HSV) that is resistant to acyclovir (ACV) poses treatment challenges in hematopoietic cell transplant (HCT) patients. We present a series of patients with ACV-resistant HSV following HCT who were successfully treated with continuous infusion high-dose ACV after failing standard treatment regimens for ACV-resistant HSV.

Publication types

Case Reports

MeSH terms

Acyclovir / administration & dosage*
Acyclovir / adverse effects
Acyclovir / therapeutic use*
Adult
Antiviral Agents / administration & dosage*
Antiviral Agents / adverse effects
Antiviral Agents / therapeutic use
Drug Resistance, Multiple, Viral
Drug Resistance, Viral*
Female
Hematopoietic Stem Cell Transplantation*
Herpes Simplex / drug therapy*
Humans
Immunocompromised Host
Infusions, Intravenous
Male
Middle Aged
Simplexvirus / drug effects*
Simplexvirus / isolation & purification
Treatment Outcome

Substances

Antiviral Agents
Acyclovir