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Comparative Study
. Jul-Sep 2010;16(3):194-7.
doi: 10.4103/1319-3767.65197.

Grape Seed Extract to Improve Liver Function in Patients With Nonalcoholic Fatty Liver Change

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Free PMC article
Comparative Study

Grape Seed Extract to Improve Liver Function in Patients With Nonalcoholic Fatty Liver Change

Manouchehr Khoshbaten et al. Saudi J Gastroenterol. .
Free PMC article

Abstract

Background/aim: Therapeutic interventions in nonalcoholic fatty liver disease are limited, while anti-oxidative materials have shown benefits in animal models. This study aimed to evaluate grape seed extract as an anti-oxidative material in this process. Therapeutic effects of grape seed extract were evaluated in comparison to vitamin C in a double-blind setting.

Materials and methods: Fifteen patients were enrolled in each group. Liver function tests were done; also, grade of steatosis and pattern of echogenicity of the liver were determined. Patients were followed up by the same evaluation repeated in first, second and third months.

Results: Mean age +/- standard deviation was 43.2 +/- 10.3 years. Grape seed extract (GSE) significantly improved the grade of fatty liver change; and resulted in significant decrease in alanine aminotransferase in patients receiving the concentrate compared to those receiving vitamin C independently, from the initial grade of steatosis.

Conclusions: This study describes the beneficial effect of using grape seed extract for three months in patients with nonalcoholic fatty liver disease. These results may improve with a longer period of follow-up.

Conflict of interest statement

Conflict of Interest: None declared.

Figures

Figure 1
Figure 1
Estimated marginal means of serum liver test results in patients receiving grape seed extract for three months (AST: aspartate transaminase, ALT: alanine transaminase, ALP: alkaline phosphatase. *: The decrease reaches statistical significance)

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