Evaluation of the Antiviral Activity of Chlorine Dioxide and Sodium Hypochlorite Against Feline Calicivirus, Human Influenza Virus, Measles Virus, Canine Distemper Virus, Human Herpesvirus, Human Adenovirus, Canine Adenovirus and Canine Parvovirus

Biocontrol Sci. 2010 Jun;15(2):45-9. doi: 10.4265/bio.15.45.


We evaluated the antiviral activity of a chlorine dioxide gas solution (CD) and sodium hypochlorite (SH) against feline calicivirus, human influenza virus, measles virus, canine distemper virus, human herpesvirus, human adenovirus, canine adenovirus and canine parvovirus. CD at concentrations ranging from 1 to 100 ppm produced potent antiviral activity, inactivating >or= 99.9% of the viruses with a 15 sec treatment for sensitization. The antiviral activity of CD was approximately 10 times higher than that of SH.

MeSH terms

  • Adenoviruses, Canine / drug effects
  • Adenoviruses, Human / drug effects
  • Antiviral Agents / pharmacology*
  • Calicivirus, Feline / drug effects
  • Chlorine Compounds / pharmacology*
  • Distemper Virus, Canine / drug effects
  • Herpesvirus 1, Human / drug effects
  • Measles virus / drug effects
  • Orthomyxoviridae / drug effects
  • Oxides / pharmacology*
  • Parvovirus, Canine / drug effects
  • Sodium Hypochlorite / pharmacology*


  • Antiviral Agents
  • Chlorine Compounds
  • Oxides
  • chlorine dioxide
  • Sodium Hypochlorite