Serum levels of 20K-hGH and 22K-hGH isoforms in acromegalic patients

Front Horm Res. 2010;38:87-93. doi: 10.1159/000318498. Epub 2010 Jul 5.


The diagnosis and treatment decisions in acromegaly depend on the measurement of growth hormone (GH) and insulin-like growth factor I (IGF-I) levels. The occurrence of different GH isoforms in the serum, mainly 22K-hGH and 20K-hGH, is a source of heterogeneity of GH results measured by different immunoassays. Since it has been previously reported that the proportion of 20K-hGH is increased in patients with active acromegaly, it might be useful to know the GH isoforms' pattern not to underdiagnose or undertreat acromegalic patients.

Publication types

  • Review

MeSH terms

  • Acromegaly / blood*
  • Human Growth Hormone / blood*
  • Humans
  • Peptide Fragments / blood*
  • Protein Isoforms


  • Peptide Fragments
  • Protein Isoforms
  • somatotropin 20K
  • Human Growth Hormone