Sumoylation of Drosophila transcription factor STAT92E

J Innate Immun. 2010;2(6):618-24. doi: 10.1159/000318676. Epub 2010 Jul 12.


STAT92E is an essential transcription factor in Drosophila melanogaster for the development of several organs and the immune system. The JAK/STAT pathway employs different evolutionary conserved regulatory mechanisms to control biological processes. Numerous transcription factors in both mammals and invertebrates have been shown to be either activated or inhibited by a covalent modification with a small ubiquitin-like modifier (Sumo). Here, we show that Drosophila STAT92E is modified by Sumo at a single lysine residue 187 in S2 cells. Mutation of Lys187 increases the transcriptional activity of STAT92E, thus suggesting that sumoylation of STAT92E has a repressive role in the regulation of the JAK/STAT pathway in Drosophila melanogaster.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • COS Cells
  • Chlorocebus aethiops
  • Drosophila Proteins / genetics
  • Drosophila Proteins / metabolism*
  • Drosophila melanogaster / physiology
  • Gene Expression Regulation, Developmental*
  • Hematopoiesis / genetics
  • Humans
  • Mutation / genetics
  • Organogenesis / genetics
  • RNA, Small Interfering / genetics
  • Repressor Proteins / genetics
  • Repressor Proteins / metabolism*
  • STAT Transcription Factors / genetics
  • STAT Transcription Factors / metabolism*
  • SUMO-1 Protein / metabolism
  • Signal Transduction / genetics
  • Sumoylation* / genetics


  • Drosophila Proteins
  • RNA, Small Interfering
  • Repressor Proteins
  • STAT Transcription Factors
  • SUMO-1 Protein
  • Stat92E protein, Drosophila