The polarization of immune cells in the tumour environment by TGFbeta

Nat Rev Immunol. 2010 Aug;10(8):554-67. doi: 10.1038/nri2808. Epub 2010 Jul 9.

Abstract

Transforming growth factor-beta (TGFbeta) is an immunosuppressive cytokine produced by tumour cells and immune cells that can polarize many components of the immune system. This Review covers the effects of TGFbeta on natural killer (NK) cells, dendritic cells, macrophages, neutrophils, CD8(+) and CD4(+) effector and regulatory T cells, and NKT cells in animal tumour models and in patients with cancer. Collectively, many recent studies favour the hypothesis that blocking TGFbeta-induced signalling in the tumour microenvironment enhances antitumour immunity and may be beneficial for cancer therapy. An overview of the current drugs and reagents available for inhibiting TGFbeta-induced signalling and their phase in clinical development is also provided.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antineoplastic Agents / pharmacology
  • Cell Polarity / immunology*
  • Cytokines / immunology
  • Dendritic Cells / immunology
  • Hematopoiesis, Extramedullary
  • Humans
  • Immunosuppression
  • Killer Cells, Natural / immunology
  • Macrophages / immunology
  • Neoplasms / immunology*
  • Neoplasms / therapy
  • Neutrophils / immunology
  • Signal Transduction / drug effects
  • T-Lymphocyte Subsets / immunology
  • T-Lymphocytes, Regulatory / immunology
  • Transforming Growth Factor beta / antagonists & inhibitors
  • Transforming Growth Factor beta / immunology*
  • Transforming Growth Factor beta / metabolism

Substances

  • Antineoplastic Agents
  • Cytokines
  • Transforming Growth Factor beta