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, 7 (2), 364-79

Alcohol Abuse in Pregnant Women: Effects on the Fetus and Newborn, Mode of Action and Maternal Treatment


Alcohol Abuse in Pregnant Women: Effects on the Fetus and Newborn, Mode of Action and Maternal Treatment

Asher Ornoy et al. Int J Environ Res Public Health.


Offspring of mothers using ethanol during pregnancy are known to suffer from developmental delays and/or a variety of behavioral changes. Ethanol, may affect the developing fetus in a dose dependent manner. With very high repetitive doses there is a 6-10% chance of the fetus developing the fetal alcoholic syndrome manifested by prenatal and postnatal growth deficiency, specific craniofacial dysmorphic features, mental retardation, behavioral changes and a variety of major anomalies. With lower repetitive doses there is a risk of "alcoholic effects" mainly manifested by slight intellectual impairment, growth disturbances and behavioral changes. Binge drinking may impose some danger of slight intellectual deficiency. It is advised to offer maternal abstinence programs prior to pregnancy, but they may also be initiated during pregnancy with accompanying close medical care. The long term intellectual outcome of children born to ethanol dependent mothers is influenced to a large extent by the environment in which the exposed child is raised.

Keywords: ethanol; fetal alcohol syndrome; pregnancy outcome.

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    1. Ornoy A. The impact of intrauterine exposure versus postnatal environment in neurodevelopmental toxicity: long-term neurobehavioral studies in children at risk for developmental disorders. Toxicol Lett. 2003;140–141:171–181. - PubMed
    1. Ornoy A. The effects of alcohol and illicit drugs on the human embryo and fetus. Isr. J. Psychiatry Relat. Sci. 2002;39:120–132. - PubMed
    1. Jones KL, Smith DW. Recognition of the fetal alcohol syndrome in early infancy. Lancet. 1973;2:999. - PubMed
    1. Lemoine P, Harousseau H, Borteyru JP, Menuet JC. Children of alcoholic parents-observed anomalies: discussion of 127 cases. Ther. Drug Monit. 2003;25:132–136. - PubMed
    1. Randall CL. Alcohol and pregnancy: highlights from three decades of research. J. Stud. Alcohol. 2001;62:554–561. - PubMed