Copper T380A intrauterine device for emergency contraception: a prospective, multicentre, cohort clinical trial

BJOG. 2010 Sep;117(10):1205-10. doi: 10.1111/j.1471-0528.2010.02652.x. Epub 2010 Jul 7.


Objective: To determine the effectiveness of the Copper T380A (CuT380A) intrauterine device (IUD) as an emergency contraceptive in women.

Design: Prospective, multicentre, cohort clinical trial.

Setting: Eighteen family planning clinics in China.

Sample: A cohort of 1963 women, aged 18-44 years, requesting emergency contraception within 120 hours of unprotected sexual intercourse.

Methods: Women requesting emergency contraception were followed at 1, 3 and 12 months after the insertion of CuT380A.

Main outcome measures: Efficacy of CuT380A as emergency contraception and for up to 12 months of postinsertion use. Insertion complication rates, reported side-effects and continuation rates at 12 months were also recorded.

Results: No pregnancies occurred prior to or at the first follow-up visit, making CuT380A 100% effective as emergency contraception in this study. The pregnancy rate over the 12-month period was 0.23 per 100 women. In all, 29 (1.5%) women experienced a difficult IUD insertion process, requiring local anaesthesia or prophylactic antibiotics. No uterine perforations occurred. The main side-effects were increased menstrual bleeding and menstrual disturbances. The 12-month postinsertion continuation rate was 94.0 per 100 woman-years.

Conclusions: CuT380A is a safe and effective method for emergency contraception. The advantages of CuT380A include its ability to provide effective, long-term contraception.

Publication types

  • Clinical Trial
  • Multicenter Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Contraception, Postcoital / methods*
  • Female
  • Humans
  • Intrauterine Devices, Copper / adverse effects
  • Intrauterine Devices, Copper / statistics & numerical data*
  • Menorrhagia / etiology
  • Middle Aged
  • Parity
  • Patient Compliance
  • Patient Satisfaction
  • Pregnancy
  • Prospective Studies
  • Treatment Outcome
  • Young Adult