High levels of serum angiogenic growth factors in patients with AL amyloidosis: comparisons with normal individuals and multiple myeloma patients

Br J Haematol. 2010 Sep;150(5):587-91. doi: 10.1111/j.1365-2141.2010.08288.x. Epub 2010 Jul 7.


Serum levels of five angiogenic cytokines were evaluated in 82 patients with primary systemic amyloidosis (AL). Angiopoietin-1, vascular endothelial growth factor, basic fibroblast growth factor and angiogenin were higher in AL patients than in controls (n = 35) and newly-diagnosed, symptomatic, myeloma patients (n = 35). Angiopoetin-1/Angiopoetin-2 ratio was lower in AL compared to controls but higher than in myeloma patients. Angiopoetin-2 correlated with cardiac dysfunction indices; however, none of the angiogenic growth factors was prognostically significant. The increased angiogenic cytokine levels observed in AL seem to represent either a toxic effect of amyloid fibrils or light chains, or a compensatory response to organ dysfunction.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Amyloidosis / blood*
  • Angiogenic Proteins / blood*
  • Angiopoietin-1 / blood
  • Biomarkers / blood
  • Fibroblast Growth Factor 2 / blood
  • Humans
  • Middle Aged
  • Multiple Myeloma / blood*
  • Neoplasm Proteins / blood
  • Ribonuclease, Pancreatic / blood
  • Vascular Endothelial Growth Factor A / blood


  • Angiogenic Proteins
  • Angiopoietin-1
  • Biomarkers
  • Neoplasm Proteins
  • VEGFA protein, human
  • Vascular Endothelial Growth Factor A
  • Fibroblast Growth Factor 2
  • angiogenin
  • Ribonuclease, Pancreatic