Cerebral perfusion information obtained by dynamic contrast-enhanced phase-shift magnetic resonance imaging: comparison with model-free arterial spin labelling

Clin Physiol Funct Imaging. 2010 Sep;30(5):375-379. doi: 10.1111/j.1475-097X.2010.00947.x. Epub 2010 Jul 2.

Abstract

Phase-shift time curves following a bolus injection of gadolinium contrast agent were registered for grey-matter regions and large vessels in 14 subjects. Deconvolving a tissue phase-shift curve with a phase-based arterial input function resulted in a tissue residue function R(t). The peak value of R(t) provided a relative cerebral blood flow (CBF) index, while the area-to-height ratio of R(t) provided quantitative mean transit time (MTT). For comparison, quantitative CBF values in grey matter were acquired using model-free arterial spin labelling (ASL). The phase-based relative CBF estimates showed good linear correlation with ASL-based CBF (r = 0.82). Grey-matter MTT was 4.9 +/- 1.1 s (mean +/- SD).

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Blood Flow Velocity
  • Cerebrovascular Circulation*
  • Contrast Media*
  • Female
  • Humans
  • Image Interpretation, Computer-Assisted
  • Linear Models
  • Magnetic Resonance Imaging*
  • Male
  • Meglumine*
  • Middle Aged
  • Models, Cardiovascular
  • Organometallic Compounds*
  • Predictive Value of Tests
  • Regional Blood Flow
  • Spin Labels*
  • Sweden
  • Time Factors

Substances

  • Contrast Media
  • Organometallic Compounds
  • Spin Labels
  • Meglumine
  • gadoterate meglumine