Assessing the human immune system through blood transcriptomics

BMC Biol. 2010 Jul 1;8:84. doi: 10.1186/1741-7007-8-84.


Blood is the pipeline of the immune system. Assessing changes in transcript abundance in blood on a genome-wide scale affords a comprehensive view of the status of the immune system in health and disease. This review summarizes the work that has used this approach to identify therapeutic targets and biomarker signatures in the field of autoimmunity and infectious disease. Recent technological and methodological advances that will carry the blood transcriptome research field forward are also discussed.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Autoimmune Diseases / blood
  • Autoimmune Diseases / genetics
  • Biomarkers / blood*
  • Communicable Diseases / blood
  • Communicable Diseases / genetics
  • Gene Expression Profiling / methods*
  • Humans
  • Immune System / metabolism*
  • Immune System / pathology


  • Biomarkers