[Expression of Mta-1 and VEGF and their correlation in the endometrial cancer]

Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2010 Jul;26(7):682-4.
[Article in Chinese]

Abstract

Aim: To explore the expression of metastasis-associated protein 1(Mta-1) and vascular endothelial growth factor (VEGF) and their correlation in the endometrial cancer.

Methods: In 62 cases of endometrial cancer and 30 cases of normal endomedium, the expression of Mta-1 and VEGF was examined with immunohistochemistry and their correlation with pathological phenotype of the endometrial cancer was analyzed.

Results: The expression of Mta-1 and VEGF in endometrial cancer was higher than that in normal endomedium (P<0.01). The expression of Mta-1 and VEGF in endometrial cancer was related to clinical stage, pathologic type, lymph node metastasis and depth of myometrial invasion (P<0.05 or P<0.01). Positive correlation was observed between VEGF and Mta-1 expression(r=0.582, P<0.05).

Conclusion: Expression of Mta-1 expression and VEGF is positively associated with the development and progression of endometrial cancer.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Case-Control Studies
  • Endometrial Neoplasms / genetics*
  • Endometrial Neoplasms / metabolism
  • Female
  • Gene Expression Regulation, Neoplastic*
  • Histone Deacetylases / genetics*
  • Histone Deacetylases / metabolism
  • Humans
  • Middle Aged
  • Repressor Proteins / genetics*
  • Repressor Proteins / metabolism
  • Trans-Activators
  • Vascular Endothelial Growth Factor A / genetics
  • Vascular Endothelial Growth Factor A / metabolism

Substances

  • MTA1 protein, human
  • Repressor Proteins
  • Trans-Activators
  • Vascular Endothelial Growth Factor A
  • Histone Deacetylases