Inhibition of herpesvirus replication and herpesvirus-induced deoxyribonucleic acid polymerase by phosphonoformate

Antimicrob Agents Chemother. 1978 Feb;13(2):188-92. doi: 10.1128/AAC.13.2.188.


Phosphonoformate was found to be an inhibitor of the deoxyribonucleic acid polymerase induced by the herpesvirus of turkeys. The apparent inhibition constants were 1 to 3 muM. Phosphonoformate was also able to block the replication in cell culture of Marek's disease herpesvirus, the herpesvirus of turkeys, and herpes simplex virus. It was as effective as phosphonoacetate. Phosphonoformate was not an effective inhibitor of a phosphonoacetate-resistant mutant of the herpesvirus of turkeys nor of its induced deoxyribonucleic acid polymerase.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Catalysis
  • Cells, Cultured
  • Formates / pharmacology
  • Herpesvirus 2, Gallid / drug effects*
  • Herpesvirus 2, Gallid / enzymology
  • Nucleic Acid Synthesis Inhibitors*
  • Organophosphorus Compounds / pharmacology*
  • Phosphonoacetic Acid / pharmacology
  • Virus Replication / drug effects*


  • Formates
  • Nucleic Acid Synthesis Inhibitors
  • Organophosphorus Compounds
  • Phosphonoacetic Acid