Short sleep duration is associated with the development of impaired fasting glucose: the Western New York Health Study

Ann Epidemiol. 2010 Dec;20(12):883-9. doi: 10.1016/j.annepidem.2010.05.002.


Purpose: To examine whether sleep duration was associated with incident-impaired fasting glucose (IFG) over 6 years of follow-up in the Western New York Health Study.

Methods: Participants (N = 1,455, 68% response rate) who were free of type 2 diabetes and known cardiovascular disease at baseline (1996-2001) were reexamined in the period 2003-2004. A nested case-control study was conducted. Cases had fasting plasma glucose (FPG) less than 100 mg/dL at baseline and 100 to 125 mg/dL at follow-up: controls (n = 272) had FPG less than 100 mg/dL at both exams. Cases (n = 91) were individually matched to three controls (n = 272) on sex, race, and year of study enrollment. Average sleep duration was categorized as short (<6 hours), mid-range (6 to 8 hours), and long (>8 hours).

Results: In multivariate conditional logistic regression after adjustment for several diabetes risk factors, the odds ratio (OR) of IFG among short sleepers was 3.0 (95% confidence limit [CL]: 1.05, 8.59) compared to mid-range sleepers. There was no association between long sleep and IFG: OR 1.6 (95% CL: 0.45, 5.42). Adjustment for insulin resistance attenuated the association only among short sleepers: OR 2.5 (95% CL: 0.83, 7.46).

Conclusions: Short sleep duration was associated with an elevated risk of IFG. Insulin resistance appears to mediate this association.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Adult
  • Aged
  • Blood Glucose / analysis*
  • Case-Control Studies
  • Diabetes Mellitus, Type 2 / etiology*
  • Fasting / blood*
  • Female
  • Follow-Up Studies
  • Glucose Tolerance Test
  • Humans
  • Insulin Resistance* / physiology
  • Logistic Models
  • Male
  • Middle Aged
  • New York / epidemiology
  • Risk Factors
  • Sleep Deprivation / blood*
  • Sleep Deprivation / epidemiology
  • Surveys and Questionnaires


  • Blood Glucose