Monocyte and macrophage biology: an overview

Semin Nephrol. 2010 May;30(3):216-33. doi: 10.1016/j.semnephrol.2010.03.002.


This review provides an overview of the current understanding of the biology of monocytes and macrophages. It focuses on four rapidly advancing areas that underpin recent conceptual advances, namely: (1) the bone marrow origins of monocytes and macrophages, (2) monocyte heterogeneity, (3) the early inflammatory consequences of tissue injury, and (4) current concepts of macrophage activation and their limitations.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Dendritic Cells / physiology
  • Humans
  • Kidney Diseases / immunology*
  • Macrophage Activation
  • Macrophages / physiology*
  • Mice
  • Monocytes / physiology*