T helper cell differentiation: understanding the needs of hierarchy

Thomas Weichhart; Marcus D Säemann

doi:10.1016/j.immuni.2010.06.008

T helper cell differentiation: understanding the needs of hierarchy

Immunity. 2010 Jun 25;32(6):727-9. doi: 10.1016/j.immuni.2010.06.008.

Authors

Thomas Weichhart¹, Marcus D Säemann

Affiliation

¹ Department of Internal Medicine III, Clinical Division of Nephrology and Dialysis, Medical University Vienna, Währinger Gürtel 18-20, A-1090 Vienna, Austria. thomas.weichhart@meduniwien.ac.at

PMID: 20620936
DOI: 10.1016/j.immuni.2010.06.008

Abstract

In this issue of Immunity, Lee et al. (2010) demonstrate that the mammalian Target of Rapamycin Complex 2 promotes the differentiation of T helper 1 (Th1) cells via the kinase Akt, whereas it independently fosters Th2 cell generation via another kinase, PKC-theta.

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