T helper cell differentiation: understanding the needs of hierarchy

Immunity. 2010 Jun 25;32(6):727-9. doi: 10.1016/j.immuni.2010.06.008.


In this issue of Immunity, Lee et al. (2010) demonstrate that the mammalian Target of Rapamycin Complex 2 promotes the differentiation of T helper 1 (Th1) cells via the kinase Akt, whereas it independently fosters Th2 cell generation via another kinase, PKC-theta.

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