MicroRNA gene regulatory pathways in the establishment and maintenance of ESC identity

Cell Stem Cell. 2010 Jul 2;7(1):31-5. doi: 10.1016/j.stem.2010.06.011.


Understanding the molecular foundations of embryonic stem cell (ESC) self-renewal and pluripotency will facilitate therapeutic exploitation of these remarkable cells. Here we discuss the emerging roles of microRNAs in the establishment and maintenance of ESC identity and summarize our current understanding of the mechanisms controlling microRNA expression and function in ESCs.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Cell Cycle / genetics
  • Cell Cycle / physiology
  • Cell Differentiation / genetics
  • Cell Differentiation / physiology
  • Embryonic Stem Cells / cytology
  • Embryonic Stem Cells / metabolism*
  • MicroRNAs / genetics
  • MicroRNAs / physiology*
  • Models, Biological
  • Signal Transduction / genetics
  • Signal Transduction / physiology*


  • MicroRNAs