MicroRNAs as regulators of differentiation and cell fate decisions

Cell Stem Cell. 2010 Jul 2;7(1):36-41. doi: 10.1016/j.stem.2010.06.012.


Unique expression domains, targets, and gain- and loss-of-function phenotypes of particular microRNAs have important implications for directed differentiation of stem cell populations and suppression of undesired cell types. We discuss this emerging topic, in part using muscle differentiation as a paradigm, and highlight common themes and unique modalities by which microRNAs exert their lineage-promoting or differentiation effects on multiple tissues.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Cycle / genetics
  • Cell Cycle / physiology
  • Cell Differentiation / genetics
  • Cell Differentiation / physiology*
  • Cell Lineage / genetics
  • Cell Lineage / physiology*
  • Embryonic Stem Cells / cytology
  • Embryonic Stem Cells / metabolism
  • Humans
  • MicroRNAs / genetics
  • MicroRNAs / metabolism*
  • Models, Biological


  • MicroRNAs