Molecular circuits of resolution in renal disease

ScientificWorldJournal. 2010 Jul 7;10:1370-85. doi: 10.1100/tsw.2010.120.

Abstract

Inflammation is a common feature of renal pathology. Lipid mediators, such as lipoxins, resolvins, and protectins, can actively promote the resolution of inflammation by inhibiting polymorphonuclear cell infiltration to the site of inflammation, shifting the cytokine milieu from proinflammatory to proresolving and increasing the nonphlogistic phagocytosis of apoptotic cells by macrophages. Here we review the evidence for molecular circuits of resolution in renal disease.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • CD59 Antigens / metabolism
  • Docosahexaenoic Acids / metabolism
  • Humans
  • Kidney Diseases / metabolism*
  • Lipoxins / metabolism

Substances

  • CD59 Antigens
  • Lipoxins
  • Docosahexaenoic Acids