Cryptolepine, isolated from Sida acuta, sensitizes human gastric adenocarcinoma cells to TRAIL-induced apoptosis

Phytother Res. 2011 Jan;25(1):147-50. doi: 10.1002/ptr.3219.

Abstract

Bioassay guided separation of Sida acuta whole plants led to the isolation of an alkaloid, cryptolepine (1), along with two kaempferol glycosides (2-3). Compound 1 showed strong activity in overcoming TRAIL-resistance in human gastric adenocarcinoma (AGS) cells at 1.25, 2.5 and 5 μm. Combined treatment of 1 and TRAIL sensitized AGS cells to TRAIL-induced apoptosis at the aforementioned concentrations.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenocarcinoma / pathology
  • Antineoplastic Agents, Phytogenic / chemistry
  • Antineoplastic Agents, Phytogenic / isolation & purification
  • Antineoplastic Agents, Phytogenic / pharmacology*
  • Apoptosis / drug effects*
  • Caspase 3 / metabolism
  • Caspase 7 / metabolism
  • Cell Line, Tumor
  • Drug Resistance, Neoplasm
  • Enzyme Activation / drug effects
  • Glycosides / chemistry
  • Glycosides / isolation & purification
  • Glycosides / pharmacology
  • Humans
  • Indole Alkaloids / chemistry
  • Indole Alkaloids / isolation & purification
  • Indole Alkaloids / pharmacology*
  • Malvaceae / chemistry*
  • Quinolines / chemistry
  • Quinolines / isolation & purification
  • Quinolines / pharmacology*
  • Stomach Neoplasms / pathology
  • TNF-Related Apoptosis-Inducing Ligand / pharmacology*

Substances

  • Antineoplastic Agents, Phytogenic
  • Glycosides
  • Indole Alkaloids
  • Quinolines
  • TNF-Related Apoptosis-Inducing Ligand
  • cryptolepine
  • Caspase 3
  • Caspase 7