Laser photocoagulation for stage 3+ retinopathy of prematurity

Ophthalmology. 1991 May;98(5):576-80. doi: 10.1016/s0161-6420(91)32247-4.


Twenty-two infants with "threshold" stage 3+ retinopathy of prematurity (ROP) were entered into a prospective, randomized clinical trial to compare the efficacy of transscleral cryotherapy versus laser photocoagulation delivered by the indirect ophthalmoscope. Eighteen infants have been followed for at least 3 months. Fifteen of 16 eyes randomized to laser and 9 of 12 eyes randomized to cryotherapy showed regression. The results suggest that laser therapy is as effective as cryotherapy in the treatment of ROP (P = 0.285).

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cryosurgery*
  • Female
  • Follow-Up Studies
  • Fundus Oculi
  • Gestational Age
  • Humans
  • Infant
  • Infant, Newborn
  • Laser Therapy
  • Light Coagulation*
  • Male
  • Prognosis
  • Prospective Studies
  • Retinopathy of Prematurity / surgery*