The IL-2 defect in systemic lupus erythematosus disease has an expansive effect on host immunity

J Biomed Biotechnol. 2010;2010:740619. doi: 10.1155/2010/740619. Epub 2010 Jun 6.

Abstract

IL-2 production is decreased in systemic lupus erythematosus (SLE) patients and affects T cell function and other aspects of host immunity. Transcription factors regulating IL-2 production behave aberrantly in SLE T cells. In addition to IL-2 dysregulation, other IL-2 family members (IL-15 and IL-21) are abnormally expressed in SLE. Decreased IL-2 production in SLE patients leads to many immune defects such as decreased T(reg) production, decreased activation-induced cell death (AICD), and decreased cytotoxicity. IL-2 deficiency results in systemic dysregulation of host immune responses in patients suffering from SLE disease.

MeSH terms

  • Animals
  • Cell Death
  • Disease Models, Animal
  • Humans
  • Immunity / immunology*
  • Interleukin-2 / biosynthesis
  • Interleukin-2 / deficiency
  • Interleukin-2 / immunology*
  • Lupus Erythematosus, Systemic / immunology*
  • Lymphocyte Activation / immunology
  • Mice
  • Receptors, Interleukin-2 / deficiency
  • T-Lymphocytes / cytology
  • T-Lymphocytes / immunology
  • T-Lymphocytes, Regulatory / cytology
  • T-Lymphocytes, Regulatory / immunology

Substances

  • Interleukin-2
  • Receptors, Interleukin-2