Physicochemical Characteristics of OxyVita Hemoglobin, a Zero-Linked Polymer: Liquid and Powder Preparations

Artif Cells Blood Substit Immobil Biotechnol. 2011 Feb;39(1):12-8. doi: 10.3109/10731199.2010.501753. Epub 2010 Jul 13.

Abstract

OxyVita-zero-link polymerized hemoglobin (OxyVita Hb) is a novel generation hemoglobin based oxygen carrier (HBOC). Our focus in this paper is to address the question of "Why is OxyVita Hemoglobin different than the previous generation of HBOCs?" Several critical related topics will be discussed: 1) OxyVita's unique chemistry; 2) the introduction of a viable powder form of OxyVita hemoglobin for dissolution in IV water or other IV fluids; 3) the physiochemical characteristics of OxyVita hemoglobin preparations; 4) the ability to formulate different products based upon specific applications; and 5) the important storage properties essential for use in a wide range of geographical locations.

MeSH terms

  • Chemical Phenomena*
  • Chemistry, Pharmaceutical
  • Drug Storage
  • Hemoglobins / chemistry*
  • Humans
  • Polymerization
  • Powders
  • Protein Multimerization*
  • Protein Structure, Quaternary

Substances

  • Hemoglobins
  • OxyVita
  • Powders