Skin and nail responses after 1 year of infliximab therapy in patients with moderate-to-severe psoriasis: a retrospective analysis of the EXPRESS Trial

Dermatology. 2010;221(2):172-8. doi: 10.1159/000317775. Epub 2010 Jul 13.


Background: The EXPRESS study demonstrated the initial efficacy of infliximab in psoriasis affecting the skin and nails.

Objective: To further assess how patients with a positive initial response to infliximab respond to 1 year of continuous infliximab treatment.

Methods: A retrospective analysis of patients with moderate-to-severe plaque and nail psoriasis who initiated and continued infliximab treatment up to week 46 was conducted.

Results: Among all nail psoriasis patients receiving 1 year of infliximab (n = 186), 74.6 and 54.1% achieved at least 75 or 90% improvement in the Psoriasis Area and Severity Index (PASI) at week 50. These PASI-75 (n = 138) and PASI-90 (n = 100) responders had respective mean improvements from baseline to week 50 of 93.6 and 97.3% for the PASI, 90.6 and 94.1% for the Dermatology Life Quality Index (DLQI) and 78.2 and 80.3% for the Nail Psoriasis Severity Index (NAPSI).

Conclusions: Infliximab treatment for 1 year produced sustained improvement in PASI, DLQI and NAPSI scores.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Antibodies, Monoclonal / therapeutic use*
  • Clinical Trials, Phase III as Topic
  • Dermatologic Agents / therapeutic use*
  • Female
  • Humans
  • Infliximab
  • Male
  • Middle Aged
  • Multicenter Studies as Topic
  • Nails / drug effects*
  • Psoriasis / drug therapy*
  • Quality of Life
  • Retrospective Studies
  • Skin / drug effects*
  • Treatment Outcome


  • Antibodies, Monoclonal
  • Dermatologic Agents
  • Infliximab