Can autism be triggered by acetaminophen activation of the endocannabinoid system?

Acta Neurobiol Exp (Wars). 2010;70(2):227-31. doi: 10.55782/ane-2010-1793.


Acetaminophen use in children has been associated with increased autism risk. Recent evidence suggests that acetaminophen's analgesic actions result from activation of the endocannabinoid system, and activation of this system can have neuromodulatory consequences during development. This investigation was performed to determine if there is evidence to support the hypothesis that acetaminophen use can trigger autism by activation of the endocannabinoid system.

MeSH terms

  • Acetaminophen / adverse effects*
  • Acetaminophen / metabolism
  • Acetaminophen / therapeutic use
  • Autistic Disorder / chemically induced*
  • Cannabinoid Receptor Modulators / metabolism*
  • Child
  • Child, Preschool
  • Endocannabinoids*
  • Fever / drug therapy
  • Humans
  • Monocytes / drug effects
  • Receptor, Cannabinoid, CB1 / metabolism*
  • Receptor, Cannabinoid, CB2 / metabolism*


  • Cannabinoid Receptor Modulators
  • Endocannabinoids
  • Receptor, Cannabinoid, CB1
  • Receptor, Cannabinoid, CB2
  • Acetaminophen