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, 6, 209-18

Tinnitus Psychopharmacology: A Comprehensive Review of Its Pathomechanisms and Management


Tinnitus Psychopharmacology: A Comprehensive Review of Its Pathomechanisms and Management

Michele Fornaro et al. Neuropsychiatr Dis Treat.


Background: Subjective tinnitus is a frequent, impairing condition, which may also cause neurotransmitter imbalance at the cochlea. Psychopharmacologic agents, although not being the first-line treatment for tinnitus, may modulate cochlear neurotransmission, thereby influencing the subjective tinnitus experience.

Method: A comprehensive review of MEDLINE literature (from January 1990-January 2010) was performed searching for: "tinnitus", major classes of psychopharmacological agents, and psychiatric disorders. The most relevant clinical evidence is reported briefly along with a concise description of the main neurotransmitters purported to be involved in tinnitus, in order to provide the reader with a rational evaluation of tinnitus therapy with psychopharmacological agents.

Results: Although strong methodological issues limit the reliability of the current results, a broad number of psychopharmacological agents have already been considered for tinnitus, both as candidate triggers or potential therapies.

Conclusions: Selected psychopharmacological drugs may play a role in the clinical management of this disorder. While the rational use of these agents for the treatment of tinnitus should not be overlooked, research should be undertaken on their neuromodulating actions at the cochlea.

Keywords: cochlea; psychopharmacology; tinnitus.

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    1. Sequist LV. Protein degradation/chaperone system and histone deacetylase pathway. J Thorac Oncol. 2009;4(11 Suppl 3):S1077–S1078. - PubMed
    1. World Health Organization . International Statistical Classification of Diseases and Related Health Problems; Tenth edition (ICD-10) Geneva, Switzerland: World Health Organization; 1992.
    1. Demeester K, van Wieringen A, Hendrickx JJ, et al. Prevalence of tinnitus and audiometric shape. B-ENT. 2007;3(Suppl 7):37–49. - PubMed
    1. Adoga AA, Adoga AS, Obindo JT. Tinnitus and the prevalence of co-morbid psychological stress. Niger J Med. 2008;17(1):95–97. - PubMed
    1. Sie KC, Rubel EW. Rapid changes in protein synthesis and cell size in the cochlear nucleus following eighth nerve activity blockade or cochlea ablation. J Comp Neurol. 1992;320(4):501–508. - PubMed

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