Identification of a 1,2,4,5-tetraoxane antimalarial drug-development candidate (RKA 182) with superior properties to the semisynthetic artemisinins

Angew Chem Int Ed Engl. 2010 Aug 2;49(33):5693-7. doi: 10.1002/anie.201001026.
No abstract available

MeSH terms

  • Alkylation
  • Antimalarials / chemical synthesis
  • Antimalarials / chemistry*
  • Antimalarials / pharmacology
  • Artemisinins / chemical synthesis
  • Artemisinins / chemistry
  • Artemisinins / pharmacology
  • Drug Resistance, Multiple
  • Plasmodium falciparum / drug effects
  • Plasmodium falciparum / isolation & purification
  • Small Molecule Libraries / chemistry
  • Spiro Compounds / chemical synthesis
  • Spiro Compounds / chemistry*
  • Tetraoxanes / chemical synthesis
  • Tetraoxanes / chemistry*
  • Tetraoxanes / pharmacology

Substances

  • Antimalarials
  • Artemisinins
  • RKA 182
  • Small Molecule Libraries
  • Spiro Compounds
  • Tetraoxanes