Interleukin-1A +4845(G> T) polymorphism is a factor predisposing to acne vulgaris

Tissue Antigens. 2010 Nov;76(5):411-5. doi: 10.1111/j.1399-0039.2010.01530.x. Epub 2010 Aug 19.


Acne vulgaris is a common chronic inflammatory skin disease of multifactorial origin. The aim of this study was to clarify whether known polymorphisms of the interleukin-1A (IL1A) and IL1RN genes play a role in the pathogenesis of acne vulgaris. A positive association was found between the minor T allele of the IL1A +4845(G>T) single nucleotide polymorphism (SNP) and acne, whereas no association was found with respect to any alleles of the variable number of tandem repeats (VNTR) polymorphism of the IL1RN gene. The severity of inflammatory acne symptoms correlated with the percentage of individuals carrying the homozygote T/T genotype. These results may help to elucidate the molecular events leading to the development of acne.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acne Vulgaris / genetics*
  • Acne Vulgaris / immunology*
  • Alleles
  • Case-Control Studies
  • Female
  • Gene Frequency
  • Genetic Predisposition to Disease
  • Humans
  • Interleukin 1 Receptor Antagonist Protein / genetics
  • Interleukin-1alpha / genetics*
  • Male
  • Minisatellite Repeats
  • Polymorphism, Single Nucleotide*
  • Retrospective Studies


  • IL1RN protein, human
  • Interleukin 1 Receptor Antagonist Protein
  • Interleukin-1alpha