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. 2010 Aug;63(8):841-53.
doi: 10.1016/j.jclinepi.2010.01.021.

"A delicate diplomatic situation": tobacco industry efforts to gain control of the Framingham Study

Janine K Cataldo  1 , Lisa A Bero, Ruth E Malone
Affiliations

"A delicate diplomatic situation": tobacco industry efforts to gain control of the Framingham Study

Janine K Cataldo et al. J Clin Epidemiol. 2010 Aug.

Abstract

Background: The Framingham Heart Study (henceforth Framingham) is among the gold standards for epidemiological research. Being a prospective cohort study of 5,000+ men and women, it provided early findings about the causes of coronary heart disease (CHD), following a cohort over the course of 24 years. After US government funding ended, the tobacco industry funded Council for Tobacco Research (CTR) provided continued funding for analyses related to smoking.

Objective: This study sought to understand the tobacco industry's motivation and activities in funding Framingham.

Study design and setting: We analyzed previously undisclosed tobacco industry documents, conducting iterative searches of the Legacy Tobacco Documents Library (http://legacy.library.ucsf.edu/), and assembled a historical case study.

Results: CTR funded Framingham to obtain full access to Framingham data. CTR planned for long-time industry consultant Carl Seltzer to reanalyze them to suggest that tobacco-related morbidity and mortality primarily resulted from "constitutional" factors, such as age or ethnicity. Once data were obtained, CTR terminated funding for the Framingham principal investigator, who disagreed with Seltzer. Seltzer's critical analyses of subsequently published work by the Framingham team created confusion about the association between CHD and cigarette smoking.

Conclusion: Researchers accepting tobacco industry funding risk losing control of data, analysis, and publication.

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Figures

Figure 1
Figure 1
February 1976 CTR hand written note: “overall mortality ratio 1.3”; “mortality ratios out”; “D [Dawber] wants causal interpretation; S [Seltzer] would go along just with a data presentation”.
See this image and copyright information in PMC

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References

    1. Framingham Heart Study. 2009. [cited October 12, 2009]; Available from: http://www.framinghamheartstudy.org/
    1. AMA. The AMA-ERF Committee for Research on Tobacco and Health at its May meeting reviewed your request for continued funding of the Heart Disease Epidemiology Study in Framingham, Massachusetts. May 27, 1970. RJ Reynolds. http://legacy.library.ucsf.edu/tid/lrj14d00.
    1. Dawber TR, BUMC Our telephone conversation, March 30, 1970. Apr 01, 1970. Council for Tobacco Research. http://legacy.library.ucsf.edu/tid/dfk46d00.
    1. Dawber TR. Apr 23, 1970. Council for Tobacco Research. http://legacy.library.ucsf.edu/tid/hfk46d00.
    1. Dawber TR. The Framingham Study: the epidemiology of atherosclerotic disease. Cambridge, Massachusetts: Harvard University Press; 1980.

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