Induction of apoptotic cell death via accumulation of autophagosomes in rat granulosa cells

Fertil Steril. 2011 Mar 15;95(4):1482-6. doi: 10.1016/j.fertnstert.2010.06.006. Epub 2010 Jul 14.

Abstract

This study evaluated the effect of autophagosome accumulation on apoptotic cell death in granulosa cells from developing follicles. Our results indicate that the accumulation of autophagosomes induces apoptotic cell death of granulosa cells through decreased bcl-2 expression and subsequent caspase activation.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Apoptosis / physiology*
  • Autophagy / physiology*
  • Cell Death / physiology
  • Female
  • Granulosa Cells / metabolism
  • Granulosa Cells / pathology*
  • Lysosomes / metabolism
  • Lysosomes / pathology*
  • Proto-Oncogene Proteins c-bcl-2 / biosynthesis
  • Rats
  • Rats, Sprague-Dawley

Substances

  • Proto-Oncogene Proteins c-bcl-2