Sessile serrated adenomas: demographic, endoscopic and pathological characteristics

World J Gastroenterol. 2010 Jul 21;16(27):3402-5. doi: 10.3748/wjg.v16.i27.3402.


Aim: To study the demographic and endoscopic characteristics of patients with sessile serrated adenoma (SSA) in a single center.

Methods: Patients with SSA were identified by review of the pathology database of Mayo Clinic Arizona from 2005 to 2007. A retrospective chart review was performed to extract data on demographics, polyp characteristics, presence of synchronous adenomatous polyps or cancer, polypectomy methods, and related complications.

Results: One hundred and seventy-one (2.9%) of all patients undergoing colonoscopy had a total of 226 SSAs. The mean (SE) size of the SSAs was 8.1 (0.4) mm; 42% of SSAs were < or = 5 mm, and 69% were < or = 9 mm. Fifty-one per cent of SSAs were located in the cecum or ascending colon. Approximately half of the patients had synchronous polyps of other histological types, including hyperplastic and adenomatous polyps. Synchronous adenocarcinoma was present in seven (4%) cases. Ninety-seven percent of polyps were removed by colonoscopy.

Conclusion: Among patients with colon polyps, 2.9% were found to have SSAs. Most of the SSAs were located in the right side and were safely managed by colonoscopy.

MeSH terms

  • Adenoma / epidemiology
  • Adenoma / pathology*
  • Colonoscopy
  • Colorectal Neoplasms / epidemiology
  • Colorectal Neoplasms / pathology*
  • Databases, Factual
  • Endoscopy
  • Humans
  • Polyps / epidemiology
  • Polyps / pathology*