Focal epithelial hyperplasia (Heck disease) related to highly active antiretroviral therapy in an HIV-seropositive child. A report of a case, and a review of the literature

SADJ. 2010 May;65(4):172-5.


Focal epithelial hyperplasia is increasingly frequently observed in rural South African communities. HIV-seropositive subjects have a higher prevalence of oral human papillomavirus (HPV) infections than immunocompetent subjects; and paradoxically, the introduction of highly active antiretroviral therapy for treatment of HIV-seropositive subjects is associated with increased frequency of focal epithelial hyperplasia. We describe a case of focal epithelial hyperplasia in an HIV-seropositive child receiving highly active antiretroviral therapy, who was successfully treated by using diode laser ablation.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Antiretroviral Therapy, Highly Active / adverse effects*
  • Child
  • Facial Dermatoses / virology
  • Female
  • Focal Epithelial Hyperplasia / chemically induced*
  • Focal Epithelial Hyperplasia / surgery
  • HIV Seropositivity / drug therapy*
  • Humans
  • Laser Therapy
  • Papillomavirus Infections / diagnosis
  • Warts / virology