Physiological low dose of estrogen-protected neurons in experimental spinal cord injury

Ann N Y Acad Sci. 2010 Jun;1199:86-9. doi: 10.1111/j.1749-6632.2009.05360.x.


A protective role for estrogen against neurodegeneration and neurotrauma has received enormous attention in recent years, unraveling multiple facets and thus establishing this steroid as a multiactive neuroprotectant. The present study briefly reports our findings on the neuroprotective efficacy of physiologically relevant low doses of estrogen in experimental spinal cord injury (SCI) in rats. The current finding further corroborates our earlier results on efficacy of pharmacological/supraphysiological levels of estrogen in SCI and adds to the significance of conducting preclinical studies on estrogen efficacy in SCI.

Publication types

  • Review

MeSH terms

  • Animals
  • Dose-Response Relationship, Drug
  • Estrogens / administration & dosage
  • Estrogens / physiology*
  • Neuroprotective Agents / pharmacology*
  • Rats
  • Spinal Cord Injuries / pathology*


  • Estrogens
  • Neuroprotective Agents