MCP-1: chemoattractant with a role beyond immunity: a review

Clin Chim Acta. 2010 Nov 11;411(21-22):1570-9. doi: 10.1016/j.cca.2010.07.006. Epub 2010 Jul 13.

Abstract

Background: Monocyte Chemoattractant Protein (MCP)-1, a potent monocyte attractant, is a member of the CC chemokine subfamily. MCP-1 exerts its effects through binding to G-protein-coupled receptors on the surface of leukocytes targeted for activation and migration. Role of MCP-1 and its receptor CCR2 in monocyte recruitment during infection or under other inflammatory conditions is well known.

Method: A comprehensive literature search was conducted from the websites of the National Library of Medicine (http://www.ncbl.nlm.nih.gov) and Pubmed Central, the US National Library of Medicine's digital archive of life sciences literature (http://www.pubmedcentral.nih.gov/). The data was assessed from books and journals that published relevant articles in this field.

Result: Recent and ongoing research indicates the role of MCP-1 in various allergic conditions, immunodeficiency diseases, bone remodelling, and permeability of blood - brain barrier, atherosclerosis, nephropathies and tumors.

Conclusion: MCP-1 plays an important role in pathogenesis of various disease states and hence MCP-1 inhibition may have beneficial effects in such conditions.

Publication types

  • Review

MeSH terms

  • Chemokine CCL2 / antagonists & inhibitors
  • Chemokine CCL2 / physiology*
  • Disease / etiology
  • Drug Delivery Systems
  • Humans
  • Immunity
  • Receptors, CCR2 / physiology

Substances

  • Chemokine CCL2
  • Receptors, CCR2