Onset of psoriasis during therapy with fluoxetine

Gen Hosp Psychiatry. 2010 Jul-Aug;32(4):446.e9-446.e10. doi: 10.1016/j.genhosppsych.2009.08.008. Epub 2009 Sep 24.


Objective: Psoriasis is a commonly diagnosed skin disorder that requires a long-term management and can have a profound impact on the quality of life of patients. Drugs that have been associated with the precipitation or exacerbation of psoriasis include lithium, beta-adrenergic receptor blocking agents and antimalarials. Despite extensive use of selective serotonin reuptake inhibitors (SSRIs) in clinical practice, there have been very few reports of selective serotonin reuptake inhibitor-related psoriasis. The main purpose of this study was to report fluoxetine-induced psoriasis in two Chinese women.

Results and conclusion: Although both patients had been taking fluoxetine for an extended period of time, the time scale of these two case studies suggests that fluoxetine played a causative role in these patients' psoriasis.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Aged
  • Bipolar Disorder / drug therapy
  • Female
  • Fluoxetine / adverse effects*
  • Fluoxetine / therapeutic use
  • Humans
  • Mood Disorders / drug therapy
  • Psoriasis / chemically induced*
  • Selective Serotonin Reuptake Inhibitors / adverse effects*
  • Selective Serotonin Reuptake Inhibitors / therapeutic use


  • Serotonin Uptake Inhibitors
  • Fluoxetine