Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Clinical Trial
. 2010 Aug;41(8):e537-40.
doi: 10.1161/STROKEAHA.110.580274. Epub 2010 Jul 15.

The ARUBA trial: current status, future hopes

J P Mohr  1 , Alan J Moskowitz, Christian Stapf, Andreas Hartmann, Karen Lord, Steven M Marshall, Henning Mast, Ellen Moquete, Claudia Scala Moy, Michael Parides, John Pile-Spellman, Rustam Al-Shahi Salman, Alan Weinberg, William L Young, Alejandrina Estevez, Inam Kureshi, Jonathan L Brisman
Affiliations
Free PMC article
Clinical Trial

The ARUBA trial: current status, future hopes

J P Mohr et al. Stroke. 2010 Aug.
Free PMC article

Abstract

Background and purpose: Report on the status of an on-going National Institutes of Neurological Disorders and Stroke (NINDS)-supported clinical trial of management of unbled brain arteriovenous malformations.

Summary of review: Begun in April 2007 with 3 centers, the trial has grown to 65 centers, and has randomized 124 patients through mid-June 2010 en route to the planned 400. The current literature continues to support the rationale for the trial.

Conclusions: ARUBA is steadily approaching its monthly randomization goals and has already reached the number needed to test the maximum published interventional complication rates against the minimum hemorrhage rates for natural history.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. www.arubastudy.org

    1. Brown RD, Jr, Wiebers DO, Torner JC, O’Fallon WM. Incidence and prevalence of intracranial vascular malformations in Olmsted County, Minnesota, 1965 to 1992. Neurology. 1996;46:949–952. - PubMed
    1. Hofmeister C, Stapf C, Hartmann A, Sciacca RR, Mansmann U, terBrugge K, Lasjaunias P, Mohr JP, Mast H, Meisel J. Demographic, morphological, and clinical characteristics of 1289 patients with brain arteriovenous malformation. Stroke. 2000;31:1307–10. - PubMed
    1. Stapf C, Labovitz DL, Sciacca RR, et al. Incidence of adult brain arteriovenous malformation hemorrhage in a prospective population-based stroke survey. Cerebrovasc Dis. 2002;13:43–46. - PubMed
    1. Stapf C, Mast H, Sciacca RR, et al. The New York Islands AVM Study: Design, study progress, and initial results. Stroke. 2003;34:e29–e33. - PubMed

MeSH terms