Short communication: PPAR gamma mediates a direct antiangiogenic effect of omega 3-PUFAs in proliferative retinopathy

Circ Res. 2010 Aug 20;107(4):495-500. doi: 10.1161/CIRCRESAHA.110.221317. Epub 2010 Jul 15.


Rationale: Omega3 long-chain polyunsaturated fatty acids (omega3-PUFAs) are powerful modulators of angiogenesis. However, little is known about the mechanisms governing omega3-PUFA-dependent attenuation of angiogenesis.

Objective: This study aims to identify a major mechanism by which omega3-PUFAs attenuate retinal neovascularization.

Methods and results: Administering omega3-PUFAs exclusively during the neovascular stage of the mouse model of oxygen-induced retinopathy induces a direct neovascularization reduction of more than 40% without altering vasoobliteration or the regrowth of normal vessels. Cotreatment with an inhibitor of peroxisome proliferator-activated receptor (PPAR)gamma almost completely abrogates this effect. Inhibition of PPARgamma also reverses the omega3-PUFA-induced reduction of retinal tumor necrosis factor-alpha, intercellular adhesion molecule-1, vascular cell adhesion molecule-1, endothelial selectin, and angiopoietin 2 but not vascular endothelial growth factor.

Conclusions: These results identify a direct, PPARgamma-mediated effect of omega3-PUFAs on retinal neovascularization formation and retinal angiogenic activation that is independent of vascular endothelial growth factor.

Publication types

  • Comparative Study
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Angiogenesis Inhibitors / administration & dosage
  • Angiogenesis Inhibitors / physiology*
  • Animals
  • Animals, Newborn
  • Cell Proliferation / drug effects
  • Disease Models, Animal
  • Fatty Acids, Omega-3 / administration & dosage*
  • Female
  • Mice
  • Mice, Inbred C57BL
  • Neovascularization, Pathologic / diet therapy
  • Neovascularization, Pathologic / metabolism*
  • Neovascularization, Pathologic / prevention & control
  • PPAR gamma / physiology*
  • Retinal Diseases / diet therapy
  • Retinal Diseases / metabolism*
  • Retinal Diseases / prevention & control
  • Vascular Endothelial Growth Factor A / physiology


  • Angiogenesis Inhibitors
  • Fatty Acids, Omega-3
  • PPAR gamma
  • Vascular Endothelial Growth Factor A