Tyrosinase inhibitory effect of quercetin 4'-O-β-D-glucopyranoside from dried skin of red onion (Allium cepa)

Nat Prod Res. 2011 Feb;25(3):256-63. doi: 10.1080/14786411003754256.

Abstract

In an effort to find a new whitening agent, we focused our attention on Allium cepa (red onion). Based on biologically guided fractionation using mushroom tyrosinase, quercetin 4'-O-β-D-glucopyranoside was isolated from the dried skin of A. cepa. Quercetin 4'-O-β-D-glucopyranoside showed tyrosinase inhibitory activity using L-tyrosine or L-DOPA as a substrate, with IC(50) values of 4.3 and 52.7 µM, respectively. Based on the results obtained, the dried skin of red onion possesses ingredients with potential for skin-whitening cosmetics with anti-tyrosinase activity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Glucosides / chemistry*
  • Glucosides / pharmacology*
  • Monophenol Monooxygenase / antagonists & inhibitors*
  • Onions / chemistry*
  • Plant Extracts / chemistry
  • Plant Extracts / pharmacology*
  • Quercetin / chemistry*

Substances

  • Glucosides
  • Plant Extracts
  • Quercetin
  • Monophenol Monooxygenase