The origin of fibroblasts and mechanism of cardiac fibrosis

J Cell Physiol. 2010 Nov;225(3):631-7. doi: 10.1002/jcp.22322.


Fibroblasts are at the heart of cardiac function and are the principal determinants of cardiac fibrosis. Nevertheless, cardiac fibroblasts remain poorly characterized in molecular terms. Evidence is evolving that the cardiac fibroblast is a highly heterogenic cell population, and that such heterogeneity is caused by the distinct origins of fibroblasts in the heart. Cardiac fibroblasts can derive either from resident fibroblasts, from endothelial cells via an endothelial-mesenchynmal transition or from bone marrow-derived circulating progenitor cells, monocytes and fibrocytes. Here, we review the function and origin of fibroblasts in cardiac fibrosis.NB. The information given is correct.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Lineage*
  • Cell Transdifferentiation
  • Coronary Vessels / pathology
  • Coronary Vessels / physiopathology
  • Endothelial Cells / pathology
  • Excitation Contraction Coupling
  • Extracellular Matrix / metabolism
  • Fibroblasts / metabolism
  • Fibroblasts / pathology*
  • Fibrosis
  • Heart Diseases / metabolism
  • Heart Diseases / pathology*
  • Heart Diseases / physiopathology
  • Humans
  • Morphogenesis
  • Myocardial Contraction
  • Myocardium / metabolism
  • Myocardium / pathology*
  • Neovascularization, Physiologic
  • Phenotype
  • Signal Transduction
  • Stem Cells / pathology