Neurobehavioral Deficits in db/db Diabetic Mice

Physiol Behav. 2010 Oct 5;101(3):381-8. doi: 10.1016/j.physbeh.2010.07.002. Epub 2010 Jul 14.

Abstract

Recent clinical studies indicate neurobehavioral disturbances in type-2 diabetics. However, there is paucity of preclinical research to support this concept. The validity of db/db mouse as an animal model to study type-2 diabetes and related complications is known. The present study was designed to investigate comprehensively the db/db mouse behavior as preclinical evidence of type-2 diabetes related major neurobehavioral complications. We tested juvenile (5-6weeks) and adult (10-11weeks) db/db mice for behavioral depression in forced swim test (FST), psychosis-like symptoms using pre-pulse inhibition (PPI) test, anxiety behavior employing elevated plus maze (EPM) test, locomotor behavior and thigmotaxis using open field test and working memory deficits in Y-maze test. Both juvenile and adult group db/db mice displayed behavioral despair with increased immobility time in FST. There was an age-dependent progression of psychosis-like symptoms with disrupted PPI in adult db/db mice. In the EPM test, db/db mice were less anxious as observed by increased percent open arms time and entries. They were also hypo-locomotive as evident by a decrease in their basic and fine movements. There was no impairment of working memory in the Y-maze test in db/db mice. This is the first report of depression, psychosis-like symptoms and anxiolytic behavior of db/db mouse strain. It is tempting to speculate that this mouse strain can serve as useful preclinical model to study type-2 diabetes related neurobehavioral complications.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Age Factors
  • Animals
  • Anxiety Disorders / complications*
  • Depressive Disorder / complications*
  • Diabetes Mellitus, Type 2 / complications
  • Diabetes Mellitus, Type 2 / physiopathology
  • Diabetes Mellitus, Type 2 / psychology*
  • Disease Models, Animal
  • Escape Reaction / physiology
  • Exploratory Behavior / physiology
  • Male
  • Matched-Pair Analysis
  • Maze Learning / physiology
  • Mice
  • Mice, Inbred C57BL
  • Mice, Mutant Strains / psychology
  • Motor Activity / physiology
  • Point Mutation
  • Psychotic Disorders / complications*
  • Receptors, Leptin / genetics*
  • Reflex, Startle / physiology

Substances

  • Receptors, Leptin