Multiple Conformations of F-actin

Structure. 2010 Jul 14;18(7):761-7. doi: 10.1016/j.str.2010.05.009.

Abstract

Actin works within eukaryotic cells to facilitate a variety of cellular processes, which are driven by the assembly of G-actin (monomeric form) into F-actin (fibrous form), and the disassembly of F-actin into G-actin. F-actin adopts multiple conformations, which are specified by interactions with various actin-binding proteins. Knowledge of the multiple conformations of actin is the key for understanding its cellular functions. Recently, we published a refined model for F-actin. In this review, based on this model, we discuss the origin, mechanism, and possible physiological significance of the multiple conformations of F-actin.

Publication types

  • Review

MeSH terms

  • Actins / chemistry*
  • Actins / physiology*
  • Models, Molecular*
  • Protein Binding
  • Protein Conformation*
  • Thermodynamics

Substances

  • Actins