Use of an immunization information system to assess the effectiveness of pentavalent rotavirus vaccine in US children

Vaccine. 2010 Aug 31;28(38):6314-7. doi: 10.1016/j.vaccine.2010.06.109. Epub 2010 Jul 15.


Immunization information systems (IISs) are accessible sources of immunization data. We validated immunization information from a local IIS against provider records and assessed the system's utility in evaluating vaccine effectiveness against rotavirus disease using a case-control study. Among the 91% of case and control patients with immunization records, 49% were in the IIS, and 97% had a provider record. Good agreement was observed across record sources (k=0.65). Vaccine effectiveness (VE) was 82% using IIS data compared to 82-88% using provider data. Controls identified through the IIS provided VE estimates similar to hospital control patients. IISs could represent a valuable source of data for effectiveness evaluations.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Validation Study

MeSH terms

  • Case-Control Studies
  • Humans
  • Infant
  • Infant, Newborn
  • Information Systems / statistics & numerical data*
  • Rotavirus Infections / prevention & control*
  • Rotavirus Vaccines / administration & dosage
  • Rotavirus Vaccines / immunology*
  • United States
  • Vaccines, Attenuated / administration & dosage
  • Vaccines, Attenuated / immunology


  • RotaTeq
  • Rotavirus Vaccines
  • Vaccines, Attenuated