Cytoplasmic viral replication complexes

Cell Host Microbe. 2010 Jul 22;8(1):77-85. doi: 10.1016/j.chom.2010.06.010.


Many viruses that replicate in the cytoplasm compartmentalize their genome replication and transcription in organelle-like structures that enhance replication efficiency and protection from host defenses. In particular, recent studies with diverse positive-strand RNA viruses have further elucidated the ultrastructure of membrane-bound RNA replication complexes and how these complexes function in close coordination with virion assembly and budding. The structure, function, and assembly of some positive-strand RNA virus replication complexes have parallels and potential evolutionary links with the replicative cores of double-strand RNA virus and retrovirus virions and more general similarities with the replication factories of cytoplasmic DNA viruses.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cytoplasm / virology*
  • Humans
  • Virion / genetics
  • Virion / physiology*
  • Virus Diseases / virology*
  • Virus Physiological Phenomena*
  • Virus Replication*
  • Viruses / genetics