Artemisinins and the Biological Basis for the PfATP6/SERCA Hypothesis

Trends Parasitol. 2010 Nov;26(11):517-23. doi: 10.1016/j.pt.2010.06.014. Epub 2010 Jul 17.

Abstract

With the advent of artemisinin resistance, it is timely to revisit the biological basis for the controversial suggestion that this class of antimalarial exerts its activity by inhibiting a calcium ATPase (PfATP6) that is most similar to sarcoplasmic endoplasmic reticulum calcium ATPases (SERCAs). Herein, evidence is discussed that relates to this hypothesis as alternative suggestions for how artemisinins might act have been reviewed elsewhere.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antimalarials / pharmacology*
  • Artemisinins / pharmacology*
  • Calcium-Transporting ATPases / drug effects*
  • Drug Resistance*
  • Humans
  • Malaria / prevention & control
  • Sarcoplasmic Reticulum Calcium-Transporting ATPases / antagonists & inhibitors*
  • Sarcoplasmic Reticulum Calcium-Transporting ATPases / drug effects*

Substances

  • Antimalarials
  • Artemisinins
  • Sarcoplasmic Reticulum Calcium-Transporting ATPases
  • Calcium-Transporting ATPases