A second signal for autophagic cell death?

Autophagy. 2010 Aug;6(6):823-4. doi: 10.4161/auto.6.6.12750.


Dictyostelium cells in monolayers in vitro lend themselves well to a study of autophagic cell death (ACD). There is no apoptosis machinery in the protist Dictyostelium, no caspase nor Bcl-2 family members (except a paracaspase whose inactivation does not alter cell death), thus there is no apoptosis that could interfere with, or substitute for, nonapoptotic cell death. Also, Dictyostelium, a eukaryote, has a haploid genome, which facilitates random insertional mutagenesis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Autophagy*
  • Dictyostelium / cytology*
  • Dictyostelium / genetics
  • Dictyostelium / metabolism
  • Genes, Protozoan
  • Models, Biological
  • Mutation / genetics
  • Protozoan Proteins / metabolism
  • Signal Transduction*


  • Protozoan Proteins