Genome-wide meta-analyses identify three loci associated with primary biliary cirrhosis

Nat Genet. 2010 Aug;42(8):658-60. doi: 10.1038/ng.627. Epub 2010 Jul 18.

Abstract

A genome-wide association screen for primary biliary cirrhosis risk alleles was performed in an Italian cohort. The results from the Italian cohort replicated IL12A and IL12RB associations, and a combined meta-analysis using a Canadian dataset identified newly associated loci at SPIB (P = 7.9 x 10(-11), odds ratio (OR) = 1.46), IRF5-TNPO3 (P = 2.8 x 10(-10), OR = 1.63) and 17q12-21 (P = 1.7 x 10(-10), OR = 1.38).

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alleles*
  • Canada
  • European Continental Ancestry Group / genetics*
  • Genome
  • Genome-Wide Association Study
  • Humans
  • Interferon Regulatory Factors
  • Liver Cirrhosis, Biliary
  • Meta-Analysis as Topic
  • Odds Ratio

Substances

  • IRF5 protein, human
  • Interferon Regulatory Factors