Effect of pu-erh tea on body fat and lipid profiles in rats with diet-induced obesity

Phytother Res. 2011 Feb;25(2):234-8. doi: 10.1002/ptr.3247.


The antiobesity and antihyperlipidaemic effects of pu-erh tea in rats with high fat diet (HFD)-induced obesity were investigated. Male Sprague-Dawley rats were randomly divided into five groups and fed varying diets for an 8-week period: control diet, HFD, and HFD supplemented with low, moderate or high doses of pu-erh tea extract (0.5 g, 2 g and 4 g/kg BW/day, respectively). Pu-erh tea significantly reduced the total body weight and the weight of various adipose pads. Pu-erh tea administration also significantly lowered plasma total cholesterol, triglyceride concentrations and low-density lipoprotein-cholesterol levels in rats with HFD-induced obesity, but did not affect high-density lipoprotein-cholesterol levels. Moreover, pu-erh tea significantly increased lipoprotein lipase, hepatic lipase and hormone-sensitive lipase activities in epididymal fat tissue in rats with HFD-induced obesity. Analysis of real-time reverse transcription-polymerase chain reaction results indicated that pu-erh tea significantly enhanced mRNA levels of hormone-sensitive lipase in rats with HFD-induced obesity. These results suggest that pu-erh tea attenuated visceral fat accumulation and improved hyperlipidemia in a rat model of HFD-induced obesity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adipose Tissue / drug effects*
  • Animals
  • Anti-Obesity Agents / pharmacology*
  • Cholesterol, LDL / blood
  • Diet
  • Epididymis / drug effects
  • Hyperlipidemias / drug therapy*
  • Hypolipidemic Agents / pharmacology*
  • Intra-Abdominal Fat / drug effects
  • Lipase / drug effects
  • Lipase / metabolism
  • Male
  • Obesity / drug therapy*
  • Plant Extracts / pharmacology*
  • Rats
  • Rats, Sprague-Dawley
  • Tea / chemistry
  • Triglycerides / blood


  • Anti-Obesity Agents
  • Cholesterol, LDL
  • Hypolipidemic Agents
  • Plant Extracts
  • Tea
  • Triglycerides
  • Lipase